Simvastatin ( Zocor ®): The manufacturer’s information for simvastatin states that you should avoid large quantities (>1 quart daily) of grapefruit juice in combination with simvastatin. ![]() The combination of atorvastatin and grapefruit juice can increase the risk of muscle pain, tenderness, and weakness or can even cause liver and kidney problems. Atorvastatin levels can also increase (but not as much) when you drink as little as an 8-ounce cup of grapefruit juice daily.
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